منابع مشابه
Toll-like receptors in atherosclerosis.
At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity. Identifying the initiators and mediators of that inflammation can provide promising avenues for...
متن کاملToll-Like Receptors in Atherosclerosis
Atherosclerosis, the leading cause of cardiovascular disease (CVD), is driven by inflammation. Increasing evidence suggests that toll-like receptors (TLRs) are key orchestrators of the atherosclerotic disease process. Interestingly, a distinct picture is being revealed for individual receptors in atherosclerosis. TLRs exhibit a complex nature enabling the detection of multiple motifs named dang...
متن کاملRole of Toll-like receptors in atherosclerosis.
To the Editor: We read with interest both the recent paper by Dunzendorfer et al1 and the accompanying commentary.2 We wish to clarify some key points. Dunzendorfer et al report that under antiatherogenic conditions of laminar flow, human coronary artery endothelial cells (ECs) express low levels of Toll-like receptor 2 (TLR2) mRNA and protein. Dunzendorfer et al also reported that TLR2 mRNA an...
متن کاملToll-Like Receptors, Their Ligands, and Atherosclerosis
Atherosclerosis is a disease characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins. TLRs, which recognize various pathogen-associated molecular patterns, are expressed in various cell types within the atherosclerotic plaque. Microbial agents are a...
متن کاملThe Role of Toll-Like Receptors in Breast Cancer
Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2013
ISSN: 1422-0067
DOI: 10.3390/ijms140714008